Limitations of Current Therapeutic Options: Limitations of Current Options Explore 2.0

LIMITATIONS OF CURRENT THERAPEUTIC OPTIONS

ONE HISTORIC APPROACH TO MICROBIOME RESTORATION
IS FECAL MICROBIOTA TRANSPLANTATION (FMT)1

Healthy Donor

Stool is harvested from a healthy donor

PATIENT WITH rCDI

Fecal sample is transplanted into the patient with rCDI

After FMT

The organisms from the donor sample restore a healthy gut microbiome in the patient

transpantation

References: 1. American Gastroenterological Association. https//www.gastro.org/practice-guidance/gi-patient-center/topic/fecal-microbiota-transplantation-fmt. Accessed August 31, 2021. 2. Tariq R, et al. Clin Infect Dis. 2019;68(8):1351-1358. 3. Bafeta A, et al. Ann Intern Med. 2017;167(1)34-39. 4. Joseph J, et al. Clin Transi Sci. 2019;12(3)206-208. 5. Guh AY, et al. N Engl J Med. 2020;382(14):1320-1330. 6. McDonald LC, et al. Clin Infect Dis. 2018;66:el-e48.

Limitations of Current Therapeutic Options

SEVERAL LIMITATIONS ARE FOUND ACROSS CLINICAL STUDIES,
DIAGNOSIS, AND TREATMENT

References: 1. American Gastroenterological Association. https//www.gastro.org/practice-guidance/gi-patient-center/topic/fecal-microbiota-transplantation-fmt. Accessed August 31, 2021. 2. Tariq R, et al. Clin Infect Dis. 2019;68(8):1351-1358. 3. Bafeta A, et al. Ann Intern Med. 2017;167(1)34-39. 4. Joseph J, et al. Clin Transi Sci. 2019;12(3)206-208. 5. Guh AY, et al. N Engl J Med. 2020;382(14):1320-1330. 6. McDonald LC, et al. Clin Infect Dis. 2018;66:el-e48.

RESTORE THE GUT MICROBIOME

RESTORE HOPE IN PATIENTS WITH RECURRENT C. difficile INFECTION

Further research is essential to ensure availability of a safe, effective, and standardized microbiota-based therapeutic that can help—along with antibiotic treatment—restore the microbiome and break the vicious cycle of recurrent C. difficile infection.

References: 1. American Gastroenterological Association. https//www.gastro.org/practice-guidance/gi-patient-center/topic/fecal-microbiota-transplantation-fmt. Accessed August 31, 2021. 2. Tariq R, et al. Clin Infect Dis. 2019;68(8):1351-1358. 3. Bafeta A, et al. Ann Intern Med. 2017;167(1)34-39. 4. Joseph J, et al. Clin Transi Sci. 2019;12(3)206-208. 5. Guh AY, et al. N Engl J Med. 2020;382(14):1320-1330. 6. McDonald LC, et al. Clin Infect Dis. 2018;66:el-e48.