Standard of Care and Predominant Risk Factors: Current Standard of Care Explore 2.0

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Current Standard of care

STANDARD OF CARE MAY BE INCOMPLETE

THE STANDARD OF CARE FOR CDI IS ALSO A
PREDOMINANT RISK FACTOR FOR RECURRENCE1-3

Up to 35% of patients with CDI will experience recurrence within 8 weeks after initial CDI diagnosis.4,5

CDI recurrence

Antibiotic treatment is commonly associated with high rates of rCDI because it6

  • Does not address the
    underlying dysbiosis
  • Has a deleterious impact
    on the microbiota
  • Negatively impacts colonization resistance

References: 1. DePestel DD, et al. J Pharm Pract. 2013;26(5):464-475. 2. Knight CL, Surawicz CM. Med Clin North Am. 2013;97(4):523-536. 3. Aukes L, et al. Open Forum Infect Dis. 2021;8(3):ofab052. 4. Lessa FC, et al. N Engl J Med. 2015;372(9):825-834. 5. Cornely OA, et al. Clin Infect Dis. 2012;55(suppl 2):s154-s161. 6. Antharam VC, et al. J Clin Microbiol. 2013;51(9):2884-2892. 7. Fitzpatrick F, et al. Clin Microbiol Infect. 2012;18(suppl 6):2-4. 8. van Nood E, et al. N Engl J Med. 2013;368(5):407-415.

Gut Microbiome Restoration

STANDARD OF CARE MAY BE INCOMPLETE

RESTORING A HEALTHY GUT MICROBI0ME IS ESSENTIAL

Thus starts a cycle of C. difficile infection and reinfection—impeding microbiome recovery, exacerbating morbidity, and creating a substantial economic burden.7

References: 1. DePestel DD, et al. J Pharm Pract. 2013;26(5):464-475. 2. Knight CL, Surawicz CM. Med Clin North Am. 2013;97(4):523-536. 3. Aukes L, et al. Open Forum Infect Dis. 2021;8(3):ofab052. 4. Lessa FC, et al. N Engl J Med. 2015;372(9):825-834. 5. Cornely OA, et al. Clin Infect Dis. 2012;55(suppl 2):s154-s161. 6. Antharam VC, et al. J Clin Microbiol. 2013;51(9):2884-2892. 7. Fitzpatrick F, et al. Clin Microbiol Infect. 2012;18(suppl 6):2-4. 8. van Nood E, et al. N Engl J Med. 2013;368(5):407-415.