Dysbiosis and C. Diff Infection 2.0 update

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Dysbiosis and C. Diff Infection

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  1. Importance of Microbial Diversity
  2. Dysbiosis and C. Diff Infection
  3. C. Diff Infection: An Urgent Public Health Threat
  4. Recurrent C. Diff Infection Burden
  5. Standard of Care as a Risk Factor
  6. Limitations of Current Therapeutic Options

The gut microbiota generally play a role in colonization resistance by which the native organisms prevent pathogenic microbes from flourishing. Disruption of the gut microbiome leads to an environment suited for the proliferation of Clostridioides difficile.1,2

When the relationship between the gut and its healthy flora becomes imbalanced, dysbiosis result…leading to an intestinal microenvironment susceptible to pathogenic insult from opportunistic bacteria, such as C. difficile—capable of causing a wide spectrum of symptoms ranging from mild diarrhea to sepsis.1

C. DIFF INFECTION: AN URGENT PUBLIC HEALTH THREAT