The gut microbiota generally play a role in colonization resistance by which the native organisms prevent pathogenic microbes from flourishing. Disruption of the gut microbiome leads to an environment suited for the proliferation of Clostridioides difficile.1,2
When the relationship between the gut and its healthy flora becomes imbalanced, dysbiosis results…leading to an intestinal microenvironment susceptible to pathogenic insult from opportunistic bacteria, such as C. diff—capable of causing a wide spectrum of symptoms ranging from mild diarrhea to sepsis.1
- Bien J, Palagani V, Bozko P. The intestinal microbiota dysbiosis and Clostridium difficile infection: is there a relationship with inflammatory bowel disease? Therap Adv Gastroenterol. 2013;6(1):53-68.
- Staley C, Khoruts A, Sadowsky MJ. Contemporary applications of fecal microbiota transplantation to treat intestinal diseases in humans. Arch Med Res. 2017;48(8):766-773.