DYSBIOSIS AND C. diff Infection
DYSBIOSIS IS MOST OFTEN CAUSED BY ENVIRONMENTAL
FACTORS, INCLUDING ANTIBIOTICS1
HOMEOSTASIS
During homeostasis, the microbiota is composed of diverse organisms known to benefit host health
STRESS DIET HYGIENE USE OF ANTIMICROBIALS
DYSBIOSIS
Pathobiont expansion
Reduced diversity
Loss of beneficial microbesDysbiosis is the disruption of the
composition and/or diversity of the
gut microbiome
References: 1. Petersen C, Round JL. Cellular Microbial. 2014;16(7):1024-1033. 2. Bien J, et al. Ther Adv Gastroenterol. 2013;6(1):53-68. 3. Staley C, et al. Arch Med Res. 2017;48(8):766-773.
DYSBIOSIS AND C. diff Infection
DISRUPTION OF THE GUT MICROBIOME LEADS TO AN ENVIRONMENT
SUITED FOR THE PROLIFERATION OF CLOSTRIDIOIDES DIFFICILE 2,3
The gut microbiota generally play a role in colonization resistance by which the native organisms prevent pathogenic microbes from flourishing.2,3
When the relationship between the gut and its healthy flora becomes imbalanced, dysbiosis results…leading to an intestinal microenvironment susceptible to pathogenic insult from opportunistic bacteria, such as C. difficile—capable of causing a wide spectrum of symptoms ranging from mild diarrhea to sepsis.2
References: 1. Petersen C, Round JL. Cellular Microbial. 2014;16(7):1024-1033. 2. Bien J, et al. Ther Adv Gastroenterol. 2013;6(1):53-68. 3. Staley C, et al. Arch Med Res. 2017;48(8):766-773.
