C. difficile infection recurs in up to 35% of cases within 8 weeks after initial C. difficile infection diagnosis.1, 2
Recurrent C. difficile infection significantly affects hospital quality metrics and reimbursement.
57% of patients with at least one CDI recurrence experienced ≥2 hospital admissions within 12 months.
Hospitalizations average 18 days for patients with recurrent CDI. The total, all-cause, and direct medical costs during 12-month period after initial C. difficile infection can range from $131K to $207K.3,4
Total, all-cause, direct medical costs during 12-month period after initial C. difficile infection.4
Feuerstadt P, et al, Healthcare resource utilization and direct medical costs associated with index and recurrent Clostridioides difficile infection: a real-world data analysis. J Med Econ. 2020;(23)6:603-609. Reprinted by permission from Informa UK Limited, trading as Taylor & Francis Ltd.
Recurrence accounts for some 75,000 to 175,000 additional cases of C. difficile infections per year in the United States.5,6 Furthermore, patients who have had a recurrence are at a higher risk of further C. difficile infections.7
After the first recurrence, it has been estimated that up to 60% of patients may develop a subsequent recurrence.3,8-11
In fact, one observational analysis found that upto 85% of patients with recurrent C. difficile infection will have a C. difficile infection-related readmission within 12 months.12
A systematic literature review found that patients with 3 or more recurrences had a mean of 5.8 inpatient visits per patient in a 12-month follow-up period.4
