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Power of the Microbiome

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A diverse microbial composition is essential to overall health. Bacteroidetes and Firmicutes, the gut’s most prevalent phyla, are vital to maintaining overall health and inhibiting C. difficile infection.

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Dysbiosis creates an insufficiency of Bacteroidetes and Firmicutes, which may lead to an environment suited for C. difficile growth.

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Antibiotic treatment—including vancomycin and fidaxomicin—address the acute infection but do not address (and possibly worsen) dysbiosis or restore the diverse microbial composition—allowing a window of vulnerability for recurrence.

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While efficacious, historic approaches to microbiome restoration—including fecal microbiota transplantation and probiotics—have disadvantages.

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Patients may face significant complications including sepsis, colectomy, and mortality. The healthcare system faces significant challenges including high admission rates, lengths of stays, and care costs.

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Mechanism of Disease

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EXPLORE THE MICROBIOME

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RESOURCES AND TOOLS

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SPEAKER PROGRAMS:
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C. Difficile infection an Urgent public health threat 30,000 annual mortality

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