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A diverse microbial composition is essential to overall health. Bacteroidetes and Firmicutes, the gut’s most prevalent phyla, are vital to maintaining overall health and inhibiting C. difficile infection.
Dysbiosis creates an insufficiency of Bacteroidetes and Firmicutes, which may lead to an environment suited for C. difficile growth.
Antibiotic treatment—including vancomycin and fidaxomicin—address the acute infection but do not address (and possibly worsen) dysbiosis or restore the diverse microbial composition—allowing a window of vulnerability for recurrence.
While efficacious, historic approaches to microbiome restoration—including fecal microbiota transplantation and probiotics—have disadvantages.
Patients may face significant complications including sepsis, colectomy, and mortality. The healthcare system faces significant challenges including high admission rates, lengths of stays, and care costs.
Mechanism of Disease
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THE BURDEN OF CDI MAY INCREASE
WHEN THE INFECTION RECURS
Can the power of the microbiome be
unlocked to break the cycle of rCDI?
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