C. difficile Infection An Urgent Threat Phase 2

Posted on by microbiomestg

C. Diff Infection:

An Urgent Public Health Threat

Alert

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  1. Importance of Microbial Diversity
  2. Dysbiosis and Recurrent C. difficile Infection
  3. Currently Approved Treatment Options
  4. Historic Microbiome Restoration Approaches
  5. Patient and Healthcare Burdens

C. diff infection requires urgent and aggressive action.

 

A major and urgent threat, according to the US Centers for Disease Control and Prevention (CDC), C. difficile infection is one of the most common healthcare-associated infections in US hospitals, affecting approximately half a million people annually.1,2

Significant complications
associated with C. difficile infection

Sepsis

SEPSIS

27%3,a

aFirst recurrence.

Colectomy

Colectomy

7%3,a

aFirst recurrence.

Heart failure

Heart Failure

43%4

Subsequent recurrence

Subsequent Recurrence

up to 60%5

Anxiety

Anxiety

13.9%6

PTSD

Ptsd

0.3%6

Depression

Depression

15.3%6

Mortality

Mortality associated with C. difficile infection:

30-day mortality rate of C. difficile infection ranges from 5% to 14% after an initial episode.2,7

A study of Medicare patients with community-acquired C. difficile infection documented a 9% mortality rate during inpatient stay.8

In a recent CDC reseach letter, patients (N=9) with severe-acute-respiratory syndrome coronavirus 2 (COVID-19) and C. difficile infection had a 44% mortality rate.9

Unfortunately, C. difficile infection may be the beginning of a vicious cycle of recurrence.